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Researchers posited that the peptide “ caused an increase in total pituitary RNA and GH mRNA, suggesting that proliferation of somatotroph cells had occurred, as confirmed by immunohistochemistry images .” Conversely, Ipamorelin might preferentially target a distinct class of receptors believed to be growth hormone secretagogue receptor 1a (GHS-R1a), commonly called ghrelin receptors, which endogenously respond to the hormone ghrelin, according to research by Jiménez-Reina et al