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Calprotectin is an FDA-cleared inflammatory biomarker capable of helping differentiate IBS from inflammatory bowel disease, and a significantly elevated result should prompt referral and conventional workup — including colonoscopy to rule out Crohn's or ulcerative colitis — not a permeability-repair protocol

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In this regard, GH-releasing hormone (GHRH)-expressing neurons induce GH release, whereas somatostatin (SST)-expressing neurons have an inhibitory effect on pituitary GH secretion (1,2)