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Patients with vitamin B12 deficiency and concurrent renal or hepatic disease may require increased doses or more frequent administration of methylcobalamin

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Another clinical trial involving healthy men and women between the ages of 70 and 90 found that regular supplementation with 500 mg of vitamin B12, 0.8 mg of folate, and 3 mg of vitamin B6 may be able to reduce serum homocysteine levels by 0.001