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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months.²¹ The semaglutide extension follows the same direction.⁶ The pattern reflects removal of appetite suppression after major weight loss

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3 La mayor parte de esta literatura proviene de un solo grupo de investigación, con replicación independiente limitada