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Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism

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Second, hyperandrogens induce endoplasmic reticulum stress (ERS) and activate the inositol-requiring enzyme 1α (IRE1α)-thioredoxin-interacting protein (TXNIP)/ROS-NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling pathway, leading to increased ROS production in GCs and theca cells (TCs)