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The tissue lacks the robust blood supply that muscles enjoy, receives constant mechanical loading that disrupts healing, and often develops fibrotic scar tissue rather than healthy organized collagen

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Too much homocysteine is strongly associated with an increased risk of heart disease.[ref] Related article: Homocysteine, genetics, and health Excess B12 and cancer growth: The other side of the picture, though, is that there may be times when limiting methionine is helpful , such as in fighting the proliferation of cancer cells