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It includes the successive oxidation and reduction of AsA and GSH with a cyclic transfer of reducing equivalents so that the plant-specific ascorbate peroxidase (APx) is able to reduce H 2 O 2 to H 2 O

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Although genetic predisposition contributes to individual susceptibility, environmental factors like lifestyle, dietary habits, and other external influences play a more substantial role in its development (Chen, Wang, et al., 2024)