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Given these challenges, there is an urgent need for the development of new experimental models that more accurately reflect the human CNS environment, as follows: 1) Innovative in vitro models: Developing advanced 3D culture systems or organoid models that replicate the cellular architecture and microenvironment of the CNS could offer more relevant insights into HIV-1 interactions with microglia and other brain cells

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For example, the Scrophularia–Panax compound Isam-Tang (IST) exerts immunomodulatory effects, providing a foundation for novel therapies targeting immune regulation in diabetes (141)