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injection two days before UUO induction and continued for a week after UUO, UUO-induced renal dysfunction, oxidative stress, and production of nitric oxide and transforming factor-1 were greatly attenuated by ALA treatment [88]

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The underlying heterogeneity of tinnitus, arising from diverse etiologies, variable symptom profiles, and differences in neural substrates, poses inherent difficulties in the development of universally effective agents