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Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies

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Challenge to the “Aging Decline” Hypothesis: Contrary to prevailing models derived from murine studies and plasma analysis, the presented data (Euro et al., 2025) suggests that systemic blood NAD+ levels remain relatively stable during healthy aging in humans, necessitating a re-evaluation of age-related NAD+ depletion theories