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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from naïve GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

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This also means that the vitamin is absorbed more directly, which may be important for individuals with poor absorption of B12 due to an underactive digestive system