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131 In neutrophils, SIRT1 inhibits IKKβ acetylation, stabilizing IκBα and preventing NF-κB nuclear translocation and downstream expression of chemokines such as CXCL1 and IL-8, reducing neutrophil recruitment
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18,122 It deacetylates STAT4, reducing its activity and inhibiting Th1 differentiation, which decreases IFN-γ production and mitigates KC activation
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