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HisF is involved in histidine biosynthesis catalyzing the closure of the imidazole ring 33

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Theoretical concerns include: Active cancer : Given the complex role of NNMT in various cancers, individuals with active malignancies should avoid NNMT inhibitors until the effects are better understood Pregnancy and lactation : No reproductive or developmental toxicity data exists Liver or kidney disease : Organ-specific effects of NNMT inhibition have not been evaluated Drug Interactions# No drug interaction studies have been conducted for 5-Amino-1MQ