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Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177–191) engineered to replicate hGH’s fat-metabolism effects without altering IGF-1 or glucose levels.¹ In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms.² ³ AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177–191)¹ Intended purpose: Stimulate fat metabolism while avoiding hGH’s growth or glucose effects² Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis³ Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1² ⁴ Development stage: Completed Phase II trials

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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Noh K.M., Koh J.Y