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Dual NOX/SGLT2 inhibitors as the hybrid compound GKT137831 (inhibitor of NOX1 and NOX4) and empagliflozin (SGLT2 inhibitor) have shown synergistic effects, improving insulin sensitivity by 40% in diabetic rodent models ( Emerging strategies focus on mitochondrial-specific antioxidants (e.g., MitoQ, SS-31), which have shown promise in preclinical and early-phase clinical trials by reducing mtROS and improving endothelial function in diabetic patients (Mason et al., 2022)