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Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

Dirty Genes™_DAO

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Since the Src-Akt-Erk axis was shown to play a vital role in decreasing astrocyte apoptosis, we hypothesized that allicin-stimulated GPX1 up-expression activated the Src-AKT-ERK axis and played an anti-apoptotic role in astrocytes after OGD treatment (Fig