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[0303] The apparent permeability coefficients (Papp) of all polypeptides were calculated using the following equation: Papp = dQ/dt x 1/A Co [0304] Where dQ/dt is the amount of solutes transported across the Caco-2 barrier in time dt, Co is the solute concentration in the apical compartment at time zero, and A is the cross- sectional area of the epithelium in contact with apical solution