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Treatment with cixutumumab plus temsirolimus, another mTORC1 inhibitor, produced no objective responses in a phase II trial in children and young adults with refractory sarcoma [192], even though, in an earlier phase I study in adult cancer patients, this treatment induced objective responses in two of three patients with Ewing sarcoma and four of 10 patients with adrenocortical carcinoma [186]
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