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The insight that changed this view is that when glucagon receptor activation occurs alongside GLP-1 activity, the net effect is a shift toward increased energy expenditure and fat oxidation rather than hyperglycemia

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doi: 10.1016/S0022-3565(25)23820-4 78 KimACajigas-Du RossCKDasarathyJBellarAStreemDWelchNet al

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